Ephedrine is used for temporary relief of shortness of breath, chest tightness, and wheezing due to bronchial asthma. Ephedrine may also be used for other conditions as determined by your doctor. Ephedrine is a decongestant and bronchodilator. It works by reducing swelling and constricting blood vessels...Before using ephedrine:Some medical conditions may interact with ephedrine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:if you are pregnant, planning to become pregnant, or are breast-feedingif you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement,if you have allergies to medicines, foods, or other substancesif you have a history of heart problems, diabetes, glaucoma, an enlarged prostate or other prostate problems, adrenal gland,problems, high blood pressure, seizures, stroke, blood vessel problems, an overactive thyroid, or severe asthma,Some medicines may interact with ephedrine. Tell your health care provider if you are taking any other medicines, especially any of the following: Do not use ephedrine if: you are allergic to this medication. you do not have a diagnosis of asthma you have a diagnosis of asthma but use prescription asthma medications if you have ever been hospitalized for asthma you are taking a monoamine oxidase (MAO) inhibitor (eg, phenelzine) now or have taken an MAO inhibitor in the last 14 days. If you do not know if your prescription drug contains an MAO inhibitor, ask your health care provider before taking this product. you have high blood pressure, heart disease, an irregular heartbeat, thyroid disease, diabetes, or difficulty in urination due to enlargement of the prostate gland or other severe heart problems Contact your doctor or health care provider before using ephedrine if any of these apply to you.Proper storage of ephedrine Store this medication at room temperature, between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep ephedrine out of the reach of children and away from pets. General information: If you have any questions about ephedrine, please talk with your doctor, pharmacist, or other health care provider. ephedrine is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. This information is a summary only. It does not contain all information about ephedrine. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Beta-blockers (eg, propranolol), cocaine, indomethacin, methyldopa, MAO inhibitors (eg, phenelzine), linezolid, oxytocic medicines (eg, oxytocin), rauwolfia derivatives (eg, reserpine), or tricyclic antidepressants (eg, amitriptyline), or ergot alkaloids (eg, dihydroergotamine) because the actions and side effects of ephedrine may be increased Bromocriptine, catechol-O-methyltransferase (COMT) inhibitors (eg, entacapone), or digoxin because the actions and side effects of these medicines may be increased,Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because its effectiveness may be decreased by ephedrine,This may not be a complete list of all interactions that may occur. Ask your health care provider if ephedrine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.How to use ephedrine: Use this medication as directed by your doctor. Check the label on the medicine for exact dosing instructions. Check the label on the medicine for exact dosing instructions.
ephedrine may be taken with or without food. If stomach upset occurs, take with food to reduce stomach irritation. If you miss a dose of ephedrine and are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Ask your health care provider any questions you may have about how to use ephedrine.
Important safety information: ephedrine may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to ephedrine. Using ephedrine alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks. If your symptoms do not improve within 7 days or if you develop a high fever, check with your doctor. If you have trouble sleeping, ask your pharmacist or doctor about the best time to take this medication. Do not take diet or appetite control medicines while you are taking ephedrine. Before you begin taking any new prescription or nonprescription medicine, read the ingredients to see if it also contains ephedrine. If it does or if you are uncertain, contact your doctor or pharmacist. Diabetes patients - ephedrine may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine. Use this medication with caution in the elderly because they may be more sensitive to its effects. Use ephedrine with extreme caution in children. Safety and effectiveness have not been confirmed. Pregnancy and breast-feeding: It is unknown if this medication can cause harm to the fetus. If you become pregnant while taking ephedrine, discuss with your doctor the benefits and risks of using ephedrine during pregnancy. Ephedrine is excreted in breast milk. If you are or will be breast-feeding while you are using ephedrine, check with your doctor or pharmacist to discuss the risks to your baby.Ephedrine Sulphate Injection Dosage and Administration General Dosage and Administration Instructions Ephedrine Sulfate Injection must be diluted before administration as an intravenous bolus to achieve the desired concentration. Dilute with normal saline or 5% dextrose in water. Inspect parenteral drug products visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not use if solution is colored or cloudy, or if it contains particulate matter. Seasoned Pro: Be Mindful of These Winter Health Hazards Seasoned Pro: Be Mindful of These Winter Health Hazards Dosing for the Treatment of Clinically Important Hypotension in the Setting of Anesthesia The recommended dosages for the treatment of clinically important hypotension in the setting of anesthesia is an initial dose of 5 to 10 mg administered by intravenous bolus. Administer additional boluses as needed, not to exceed a total dosage of 50 mg.Adjust dosage according to the blood pressure goal (i.e., titrate to effect).Prepare a 5 mg/mL Solution for Bolus Intravenous Administration For bolus intravenous administration, prepare a solution containing a final concentration of 5 mg/mL of Ephedrine Sulfate Injection: Withdraw 50 mg (1 mL of 50 mg/mL) of Ephedrine Sulfate Injection and dilute with 9 mL of 5% Dextrose Injection or 0.9% Sodium Chloride Injection and maintain at room temperature. Discard diluted solution after 24 hours. Withdraw an appropriate dose of the 5 mg/mL solution prior to bolus intravenous administration. Dosage Forms and Strengths Ephedrine Sulfate Injection, USP is supplied as 1 mL ampule that contains 50 mg/mL ephedrine sulfate equivalent to 38 mg ephedrine base.Warnings and Precautions Pressor Effect with Concomitant Oxytocic Drugs Serious postpartum hypertension has been described in patients who received both a vasopressor (i.e., methoxamine, phenylephrine, ephedrine) and an oxytocic (i.e., methylergonovine, ergonovine) [see Drug Interactions (7)]. Some of these patients experienced a stroke. Carefully monitor the blood pressure of individuals who have received both ephedrine and an oxytocic. Tolerance and Tachyphylaxis Data indicate that repeated administration of ephedrine can result in tachyphylaxis. Clinicians treating anesthesia-induced hypotension with Ephedrine Sulfate Injection should be aware of the possibility of tachyphylaxis and should be prepared with an alternative pressor to mitigate unacceptable responsiveness. Risk of Hypertension When Used Prophylactically When used to prevent hypotension, ephedrine has been associated with an increased incidence of hypertension compared with when ephedrine is used to treat hypotension. Adverse Reactions The following adverse reactions associated with the use of ephedrine were identified in the clinical literature. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency reliably or to establish a causal relationship to drug exposure. Gastrointestinal disorders: Nausea, vomiting Cardiac disorders: Tachycardia, palpitations (thumping heart), reactive hypertension, bradycardia, ventricular ectopics, R-R variability Nervous system disorders: Dizziness Psychiatric disorders: Restlessness